Synthesis, Spectroscopic Characterization and Biological investigation of Cu2+, Ni2+ and Zn2+ complexes with S-p-chlorobenzyl-β-N-(4-dimethylaminophenyl) methylenedithiocarbazate

The complexes of M(Db-scdtc)2 type [ Cu(Db-scdtc)2, Ni(Db-scdtc)2, and Zn(Db-scdtc)2] were synthesized by reaction S-p-chlorobenzyl-β-N-(4-dimethylaminophenyl)methylenedithiocarbazate (H-Db-scdtc) metal acetate salts in which Db-scdtc is anionic form S-p-chlorobenzyl-β-N-(4-dimethylaminophenyl)methylenedithiocarbazate. ligand characterized UV-Vis, Infrared spectroscopy, NMR (H1 C13), elemental analysis Molar conductance, Magnetic moment. moment Data suggest that central zinc ion complex forms a four-coordinate tetrahedron with two bidentate Schiff base ligands shows tetrahedral geometry, while copper nickel exhibited square planar geometry. biological activity experiment adopted the well diffusion method. Preliminary studies showed dithiocarbazate has significant inhibitory effect on proliferation pathogenic strains compared to complexes. Moreover, Cu2+ prominent antibacterial against Salmonella typhi Staphylococcus aureus. In addition, Ni2+ good antifungal Candida albicans.